Acquired reactive perforating collagenosis (ARPC) is a skin disease characterized by multiple itchy nodules, which is notably similar to the skin eruptions of prurigo nodularis (PN). The aim of this study was to prove the clinicopathological differences between ARPC and PN.

Acquired perforating dermatosis is a group of skin disorders in adults, histologically characterized by transepidermal elimination (TEE) of dermal tissue components. It includes acquired reactive perforating collagenosis (ARPC), perforating folliculitis, elastosis perforans serpiginosa, Kyrle’s disease, perforating calcifying elastosis, and perforating granuloma annulare. Faver et al. stated the diagnostic criteria of ARPC as follows: age of disease onset after 18 years, the presence of umbilicated papules or nodules with a central adherent plug, and the elimination of necrotic collagen tissue within an epithelium-lined crater. In addition, itch, scratching, and the presence of Koebner’s phenomenon are important as clinical characteristics.

Prurigo nodularis (PN) is also characterized by multiple itchy nodules in adults. As TEE is the most important point to distinguish between ARPC and PN, serial sections are often needed to find TEE. Thus, in this study, we aimed to find out other factors than TEE in the histopathology and laboratory data for better indicators to distinguish ARPC and PN.

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Kathy Andrews
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Journal of Clinical & Experimental Dermatology Research