Eosinophilic Dermatosis of Hematologic Malignancy (EDHM) is an uncommon skin disorder which may be easily misdiagnosed. Careful evaluation of the skin and lymph nodes with prompt referral to an oncologist for evaluation will hasten the diagnosis and treatment of Chronic Lymphocytic Leukemia (CLL) or other hematologic malignancy. Treatment of the underlying disease will resolve the annoying, chronic, recurrent, pruritic and painful “persistent insect-bite-like reactions” now named EDHM. We report a case of EDHM, which resolved following quick recognition of the skin condition and subsequent treatment of CLL with rituximab.

In a healthy body, different types of blood stem cells are produced that mature into red blood cells, lymphocytes (white blood cells), and platelets. In CLL, a higher-than-normal amount of blood stem cells become abnormal lymphocytes, as opposed to healthy white blood cells. These abnormal lymphocytes, also called leukemia cells, cannot fight infection like normal white blood cells do. In addition, as the leukemia cells multiply in the bone marrow and blood, they leave little room for healthy blood cells to survive. This can lead to anemia, infection, and easy bleeding.

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Regards,

Kathy Andrews
Journal Manager
Journal of Clinical & Experimental Dermatology Research
Email: derma@peerreviewedjournals.com

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